Mutagenicity,carcinogenicity and teratogenicity of vanadium compounds |
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| Affiliation: | 1. Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, United States;2. Member RIFM Expert Panel, Department of Dermatology, Columbia University Medical Center, 161 Fort Washington Ave., New York, NY 10032, United States;3. Member RIFM Expert Panel, Department of Occupational & Environmental Dermatology, Malmo University Hospital, Sodra Forstadsgatan 101, Entrance 47, Malmo SE-20502, Sweden;4. Member RIFM Expert Panel, 230 Whittier Research Center, University of Nebraska Lincoln, Lincoln, NE 68583-0857, United States;5. Member RIFM Expert Panel, School of Veterinary Medicine and Animal Science, Department of Pathology, University of Sao Paulo, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo CEP 05508-900, Brazil;6. Member RIFM Expert Panel, Department of Toxicology, University of Wuerzburg, Versbacher Str. 9, Würzburg 97078, Germany;7. Member RIFM Expert Panel, Oregon Health Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, United States;8. Member RIFM Expert Panel, Department of Biochemistry, Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, United States;9. Member RIFM Expert Panel, Department of Dermatology, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan;10. Member RIFM Expert Panel, College of Veterinary Medicine, Department of Comparative Medicine, The University of Tennessee, 2407 River Dr., Knoxville, TN 37996-4500, United States;11. Member RIFM Expert Panel, Department of Pharmacology, College of Medicine, University of Arizona, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ 85724-5050, United States |
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| Abstract: | The mutagenic, carcinogenic and teratogenic effects of vanadium and its compounds are reviewed. It is concluded that vanadium is not clastogenic and only weakly mutagenic; it has marked mitogenic activity affecting the distribution of chromosomes during mitosis and possibly causing aneuploidy. The few positive data on effects of vanadium during development leave it open whether direct effects on the embryo or fetus or physiological disturbances in the mother are responsible. No data exist indicating that vanadium is carcinogenic in animals or man, but since it interferes with mitosis and chromosome distribution, the possibility that vanadium might be carcinogenic under certain conditions cannot be dismissed offhand. |
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