Prostaglandin E2/parathyroid hormone-induced suppression of alkaline phosphatase activity is mediated by protein kinase C |
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| Affiliation: | 1. Department of Endocrinology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510999, China;2. State Key Laboratory of Organ Failure Research, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;3. Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou 510515, China;4. Department of Nephrology, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou 510999, China;1. School of Psychology, University of Queensland, St. Lucia, QLD, Australia;2. Department of Culture Studies, Tilburg University, Tilburg, Netherlands |
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| Abstract: | - 1.1. Bone resorptive factors, prostaglandin E2 and parathyroid hormone are shown to suppress alkaline phosphatase activity in a rat osteoblastic cell line.
- 2.2. Phorbol myristate acetate, but not dibutyryl cAMP or calcium ionophore can suppress alkaline phosphatase activity.
- 3.3. The protein kinase C inhibitors (H89, staurosporine) are able to block the suppression of alkaline phosphatase activity induced by prostaglandin E2 and parathyroid hormone.
- 4.4. These data suggest that protein kinase C is involved in the inhibition of alkaline phosphatase activity induced by prostaglandin E2 and parathyroid hormone.
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