Postprandial increase in the duodenal pH and the effect of intravenous secretin injection on ionic compositions of duodenal fluid and plasma in sheep |
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| Institution: | 1. University of Bonn, Institute for Animal Science, Katzenburgweg 7-9, 53115 Bonn, Germany;2. Chamber of Agriculture North Rhine-Westphalia, Center of Agriculture Haus Riswick, Elsenpaß 5, 47533, Kleve, Germany;3. Christian-Albrechts-University, Institute of Animal Breeding and Husbandry, Olshausenstr 40, 24098 Kiel, Germany;4. Educational and Research Centre for Animal Husbandry, Hofgut Neumuehle, 67728 Münchweiler an der Alsenz, Germany;5. Landwirtschaftliches Zentrum Baden-Württemberg (LAZBW), Atzenberger Weg 99, 88326 Aulendorf, Germany;6. Bavarian State Research Center for Agriculture, Institute for Animal Nutrition and Feed Management, Prof-Dürrwaechter-Platz 3, 85586 Poing, Germany;7. Center for Agricultural Learning, Markgrafenstraße 1, 91746 Weidenbach, Germany;8. Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Bundesallee 37, 38116 Braunschweig, Germany;9. Institute for the Biology of Farm Animals (FBN), Institute of Nutritional Physiology “Oskar Kellner”, Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany;10. TiDa Tier und Daten GmbH, Bosseer Street 4c, 24259 Westensee, Brux, Germany;1. Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Department of Medical Biology and Biochemistry, Department of Ecology and Environmental Protection, M. Skłodowska-Curie St. 9, PL 85-094 Bydgoszcz, Poland;2. University of Zielona Góra, Faculty of Biological Sciences, Department of Biotechnology, Prof. Z. Szafran St. 1, PL 65-516 Zielona Góra, Poland;3. University of Zielona Góra, Faculty of Biological Sciences, Department of Nature Protection and Biodiversity, Prof. Szafran St. 1, PL 65-516 Zielona Góra, Poland;4. University of Zielona Góra, Faculty of Biological Sciences, Department of Zoology, Prof. Z. Szafran St. 1, PL 65-516 Zielona Góra, Poland;5. Nicolaus Copernicus University, Department of Ecology and Biogeography, Lwowska St. 1, PL 87-100 Toruń, Poland;6. University of Prešov, Faculty of Humanities and Natural Sciences, Laboratory and Museum of Evolutionary Ecology, Department of Ecology, 17. novembra 1, SK-081 16 Prešov, Slovakia;7. University of Technology and Life Sciences, Faculty of Agriculture and Biotechnology, Department of Agricultural Chemistry, Seminaryjna St. 5, PL 85-326 Bydgoszcz, Poland;8. Nicolaus Copernicus University, Collegium Medicum in Bydgoszcz, Department of Medical Biology and Biochemistry, Karłowicz St. 24, PL 85-092 Bydgoszcz, Poland;1. Dehkad-e-Shir Dairy Farm, Qom, Iran;2. Department of Animal Science, Faculty of Agriculture and Natural Resources, Arak University, 38156, Arak, Iran;3. Department of Animal Science, University of Zanjan, 45371-38791, Zanjan, Iran;1. School of Veterinary Medicine and Animal Science, Federal University of Mato Grosso do Sul, Campo Grande, Brazil;2. Laboratory of Natural Products and Mass Spectrometry (LaPNEM), School of Pharmaceutical, Food and Nutrition Sciences (FACFAN), Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil;1. University of Turin, Department of Agricultural, Forest and Food Sciences (DISAFA), Largo P. Braccini 2, 10095 Grugliasco (Turin), Italy;2. INRA, UMR 1213 Herbivores, F-63122 Saint-Genès-Champanelle, France;3. Clermont Université, VetAgro Sup, UMR Herbivores, BP 10448, F-63000 Clermont-Ferrand, France;4. Associazione Regionale Allevatori del Piemonte, Via Livorno 60, 10144 Turin, Italy;5. UE1296 Monts-d’Auvergne, INRA, F-63210 Orcival, France;1. Animal and Fish Production Department, Faculty of Agriculture (Saba Basha), Alexandria University, Egypt;2. Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Estado de México, Mexico;3. Department of Animal Science, University of Abuja, Abuja, Nigeria;4. Dairy Science Department, National Research Centre, 33 Bohouth St. Dokki, Giza, Egypt;5. Universidad Autónoma del Estado de Hidalgo, Instituto de Ciencias Agropecuarias, Área Académica de Medicina Veterinaria y Zootecnia, Mexico;6. Unidad Académica de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Guerrero, Altamirano P.O. 40660, Mexico |
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| Abstract: | Testing five castrated male sheep with a pH-electrode inserted into the duodenal digesta through a T-shaped cannula, we found that the pH of the duodenal digesta was significantly increased from 3.11 ± 0.11 to 3.47 ± 0.09 after a meal. Secretin (2.5 CHR U/kg) was intravenously injected to mimic the duodenal pH increase. The administration significantly increased the duodenal digesta pH from 3.32 ± 0.18 to 4.85 ± 0.61, which was accompanied by an increase in sodium concentration, but by a decrease in potassium and chloride concentrations. It also significantly decreased the arterial blood pH from 7.543 ± 0.002 to 7.515 ± 0.008, which was accompanied by a reduced plasma HCO−3 concentration. From these results, we conclude that in sheep, feeding increases the duodenal digesta pH, and the postprandial pH increase in the duodenal fluid would be due to the raised HCO−3 secretion from the gastrointestinal tract. |
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