Tissue lipoperoxidation and glutathione peroxidase activity in puromycin aminonucleoside injected rats |
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| Affiliation: | 1. Department of Orthopaedics, China-Japan Union Hospital, Jilin University, Changchun, China;2. Department of Toxicology, School of Public Health, Jilin University, Changchun, China;1. Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, GA 30912-2000, USA;2. James and Jean Culver Vision Discovery Institute, Augusta, GA 30912-2000, USA;3. Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912-2000, USA;4. Department of Ophthalmology, Medical College of Georgia, Georgia Regents University, Augusta, GA 30912-2000, USA;5. Harold L. Dorris Neurological Research Institute, The Scripps Research Institute, La Jolla, CA 92037, USA;1. Nanjing Key Laboratory of Pediatrics, Children’s Hospital of Nanjing Medical University, Nanjing, China;2. Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing, China;3. Department of Nephrology, State Key Laboratory of Reproductive Medicine, Children’s Hospital of Nanjing Medical University, Nanjing, China;4. Renal Division, Peking University First Hospital, Beijing, China;1. Division of Foodborne, Waterborne, and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA;2. Tennessee Department of Health, Nashville, TN;3. Minnesota Department of Health, Saint Paul, MN;4. Oregon Public Health Division, Portland, OR;5. Georgia Department of Public Health, Atlanta, GA;6. New York State Emerging Infections Program, Albany, NY;7. Connecticut Emerging Infections Program, New Haven, CT;8. New Mexico Emerging Infections Program, Albuquerque, NM;9. Maryland Department of Health and Mental Hygiene, Baltimore, MD |
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| Abstract: | - 1.1. Lipoperoxidation (LPx) and glutathione peroxidase (GPx) activity were measured in kidney, liver, heart, lung, brain and testis from control and puromycin aminonucleoside (PAN) injected rats on days 1–6, 8, 10, 16 and 22 after vehicle or PAN injection.
- 2.2. PAN-injected rats developed proteinuria on day 3.
- 3.3. In PAN-injected rats: (a) LPx increased in kidney, liver, lung, brain and testis before day 3 and in heart on day 3; (b) GPx activity increased in kidney, liver, heart, lung and testis and diminished in brain on day 3 or after.
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