Characterization of zymosan-induced arthritis in the rat: Effects on joint inflammation and cartilage metabolism |
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| Institution: | 1. CHU de Bordeaux, 33076 Bordeaux, France;2. CEIP-Addictovigilance Marseille, 13385 Marseille, France;3. CEIP-Addictovigilance Grenoble, 38043 Grenoble, France;4. CEIP-Addictovigilance Toulouse, 31000 Toulouse, France;5. CEIP-Addictovigilance Nantes, 44093 Nantes, France;6. CEIP-Addictovigilance Montpellier, 34295 Montpellier, France;7. CEIP-Addictovigilance Caen, 14033 Caen, France;8. CEIP-Addictovigilance Lille, 59037 Lille, France;9. CEIP-Addictovigilance Lyon, 69460 Lyon, France;10. CEIP-Addictovigilance Poitiers, 86021 Poitiers, France;11. CEIP-Addictovigilance Clermont-Ferrand, 63003 Clermont-Ferrand, France;12. CEIP-Addictovigilance Paris, 75475 Paris, France;13. CEIP-Addictovigilance Nancy, 54511 Nancy, France;14. CEIP-Addictovigilance de Bordeaux, CHU de Bordeaux, Bordeaux, France;1. Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior SN, Ciudad Universitaria, CP 04510 Coyoacán, México DF, Mexico;2. Laboratory of Food Colour and Quality, Department of Nutrition and Food Science, Faculty of Pharmacy, Universidad de Sevilla, 41012 Sevilla, Spain;1. Unigen Inc., 3005 1st Ave., Seattle, WA 98121, USA;2. Unigen Inc., #450-86, Maebong-Ro, Dongnam-Gu, Cheonan-Si, Chungnam 330-863, Republic of Korea;1. Department of Physiology, College of Medicine, Nanchang University, Nanchang 310006, China;2. Department of Experimental Teaching, College of Medicine, Nanchang University, Nanchang 310006, China;3. Department of Tissue Embryology of Basic Medical College, Nanchang 310006, China;4. The First Affiliated Hospital of Obstetrics and Gynecology, Nanchang 310006, China;1. Chinese Medicine Toxicological Laboratory, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;2. Drug Safety Evaluation Center, Heilongjiang University of Chinese Medicine, Harbin 150040, PR China;1. Laboratory of Immunology and Molecular Biology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil;2. Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Campinas, SP, Brazil |
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| Abstract: | A single intra-articular (ia) injection of 2 mg zymosan on D0 led to the production of acute periarticular edema followed by subacute erosive synovitis. The development of the zymosan-induced arthritis was associated with an initial loss of running activity and with an initial decrease of proteoglycan synthesis. Febrile response was present only on D1. In addition, on D20 synovial pannus led to a marked depletion of the proteoglycan content in the articular cartilage. When injected ia, IL1β (1 μg) provoked similar fever and similar changes in cartilage anabolism, but did not affect cartilage proteoglycan content (D20). These results suggest that zymosan-induced synovitis in the rat combines early prostaglandin-dependent processes (edema, pain, fever) with IL1-related effects on cartilage metabolism, thus allowing evaluation of chondroprotective drugs. |
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