Altered glucose tolerance in rats exposed to maternal low protein diets in utero |
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| Institution: | 1. Department of Human Nutrition, University of Southampton, Southampton S09 3TU, U.K.;1. Electrocardiology Service, Medical Clinic Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), Brazil;2. Echocardiography Laboratory, Radiology Institute (InRad), HCFMUSP, Brazil;3. Bariatric Surgery Unit, Gastroenterology Department, HCFMUSP, Brazil;4. Institute of Mathematics and Statistics, Department of Statistics, IMEUSP, Brazil;1. Department of Nutrition, Federal University of Piauí, 64607-670 Picos, Brazil;2. Department of Physical Therapy, Federal University of Pernambuco, 50670-901 Recife, Brazil;3. Faculty of Applied Sciences, University of Campinas, 13084-970 Campinas, Brazil;4. Department of Anatomy, Federal University of Pernambuco, 50670-901 Recife, Brazil;5. Neuro Centre Magendie, INSERM U862, Université Bordeaux 2, 33077 Bordeaux, France;6. Department of Nutrition, Federal University of Pernambuco, 50670-901 Recife, Brazil;7. Department of Nursing, CAV, Federal University of Pernambuco, 55608-680 Vitória de Santo Antão, Brazil;1. Department of Endocrinology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China;2. Division of Emergency Critical Care Medicine, Department of Emergency Medicine, Brigham and Women’s Hospital, Harvard Medical School, Harvard University, Boston 02115, USA;1. Inserm, Centre d’Investigations Cliniques-Plurithématique, Inserm U1116, CHRU Nancy, Université de Lorraine, Nancy, France;2. F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France;3. Division of Cardiology, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy;4. Service de Cardiologie, Institut Lorrain du Cœur et des Vaisseaux, Centre Hospitalier Universitaire de Nancy, Nancy, France;5. Icahn School of Medicine at Mount Sinai, New York, New York;6. School of Medicine, Cardiff University, Cardiff, United Kingdom;1. Division of Medical Physiology, Department of Biomedical Sciences, Stellenbosch University, South Africa;2. Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Osun State, Nigeria;1. Programa de Pós-graduação em Ciências Farmacêuticas, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil;2. Programa de Pós- graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Av. Roraima, 97105-900, Santa Maria, RS, Brazil |
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| Abstract: | The response to an intravenous glucose load was evaluated in four groups of rats following fetal exposure to maternal diets containing 18, 12, 9 or 6% protein. The animals differed nutritionally only in terms of this prenatal experience. Animals in the 6% protein exposed group exhibited lower body weights at all ages, whilst the body weights of 9 and 12% protein exposed rats did not differ from the control group. At 9 weeks of age, a 2 g/kg body weight intravenous glucose load was cleared in 60 min by 18% protein exposed, control rats and 12% protein exposed rats. Peak blood glucose concentrations in these animals were 27.2 and 27.1 mM, respectively. Rats exposed to 9% protein in utero also cleared the glucose load in 60 min, but peak blood glucose concentrations were lower (24.4 mM), and the area under the glucose tolerance curve was 28% lower than in controls. Rats in the 6% protein exposed group cleared the glucose load in 40 min and peak blood glucose levels were only 22.1 mM. The area under the glucose tolerance curve was reduced by 40% relative to controls. When the glucose tolerance test was repeated in animals aged 44 weeks, no differences in peak glucose concentrations, area under the curve or rates of glucose clearance were observed. In utero exposure of rats to maternal low protein diets has been shown, therefore, to alter glucose tolerance in young adulthood through an, as yet, undefined mechanism. |
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