The migration of bone marrow cells to thymic culture supernatants is inhibited by stress |
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| Institution: | 1. Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, the University of Melbourne, Parkville, Australia;2. Murdoch Children''s Research Institute, Melbourne, Australia;3. Deparment of Paediatrics, the University of Melbourne, Parkville, Australia;4. Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine, Melbourne, Australia;5. Cardiothoracic Surgery, Royal Children''s Hospital, Melbourne, Australia;6. Federation University Australia, Ballarat, Australia |
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| Abstract: | The effect of immobilization stress on precursor cell migration from bone marrow to the thymus was studied in C57BL/6 mice. The in vitro migration assays, using Nuclepore chambers, showed that precursor cell migration to thymus supernatants was strongly inhibited in stressed animals. This inhibition of migration seemed to be cell-associated what can explain the thymic involution observed in mice under stress conditions. The migration of precursor cells from bone marrow may be one of the mechanisms by which the thymus gland is involuted by stress. |
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