Increases in chromosome aberrations and in abnormal sperm morphology in rubber factory workers |
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| Affiliation: | 1. Centro Nacional de Investigaciones Científicas, Departamento Productos Naturales, Laboratorio Mutagénesis, 25 y 158 Cubanacán, Apartado 6880, Havana, Cuba;2. Centro de Química Farmacéutica, Apartado 6990, Havana, Cuba;3. Hospital Materno Eusebio Hernandez, Havana, Cuba;1. Nutrition Research Center, Student Research Committee, Department of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;2. Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;3. Nutrition Research Center, Student Research Committee, Department of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;4. Department of Epidemiology, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran;5. Department of Internal Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;6. Department of Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;1. Department of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan;2. Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital, Hiroshima, Japan;3. Department of Biostatistics and Data Science, Osaka University Graduate School of Medicine, Osaka, Japan;4. Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan;5. Department of Physiol Therapy, Hiroshima International University, Hiroshima, Japan;6. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan;7. Department of Stem Cell Biology and Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima, Japan;1. Health Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran;2. Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Noor Research Center for Ophthalmic Epidemiology, Noor Eye Hospital, Tehran, Iran;4. Refractive Errors Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;1. Departamento de Ciências, Faculdade de Formação de Professores da Universidade do Estado do Rio de Janeiro, Rua Dr. Francisco Portela 1470 - Patronato, São Gonçalo, RJ, 24435-005, Brazil;2. Laboratório de Neurofisiologia, Departamento de Ciências Fisiológicas, Instituto de Biologia Roberto Alcantara Gomes, Centro Biomédico, Universidade do Estado do Rio de Janeiro (UERJ), Av. Prof. Manuel de Abreu 444, 5 andar – Vila Isabel, Rio de Janeiro, RJ, 20550-170, Brazil;1. Michael E. DeBakey Veterans Affairs Medical Center, United States;2. Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, United States;3. Center for Innovations in Quality, Effectiveness and Safety, United States;4. VA South Central Mental Illness Research, Education, and Clinical Center, United States |
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| Abstract: | Subjects working at a rubber plant in a chemicals warehouse or in calandering and bambury units were analyzed for both sperm parameters and structural chromosome aberrations in peripheral blood lymphocytes. Sperm analysis war performed in a group of 24 workers for comparison with fertile (n = 24) and infertile (n = 24) control groups. The statistical analyses of semen volume, vitality and sperm count did not show significant differences between exposed and fertile groups but significant differences were found from the infertile group. A significantly lower proportion of normal sperm head shapes was found in exposed subjects when compared to the fertile group (40.1 vs. 57.8). Seven exposed workers were re-analyzed 1 year and their sperm parameters did not change. The cytogenetic analysis showed a significant increase (3.90%) in the percentage of cells with aberrations in bambury workers (n = 11). However, no differences were found between calandering workers (n = 8) and control subjects (n = 10). Workplace air samples taken on the day of tissue sampling did not show any increase above the Cuban maximal allowed concentration for benzo[a]pyrene or toluene. |
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