Clozapine attenuates cocaine conditioned place preference |
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| Institution: | 1. Translational Medicine and Neurogenetics, Institut de Génétique et de Biologie Molé-culaire et Cellulaire, INSERM U-964, CNRS UMR-7104, Université de Strasbourg, France;2. Inserm U-1114, Department of Psychiatry, University of Strasbourg, France;3. Department of Psychiatry and Addictology, University Hospital of Dijon, France, EA 4452, LPPM, University of Burgundy, France;4. CHRU de Strasbourg-INSERM1114, Department of Psychiatry, University of Strasbourg, France;5. McGill Group for Suicide Studies, Douglas Mental Health research Centre, McGill University, Montréal, Canada;6. Douglas Mental Health Research Centre, McGill University, Montréal, Canada |
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| Abstract: | Clozapine, an atypical neuroleptic, has dopamine and serotonin antagonist actions that suggest its potential as a cocaine abuse pharmacotherapy. Yet, self-administration and discriminative stimulus studies in animals have reported both an enhancement and a partial blockade of cocaine's behavioral effects with clozapine. The present study examines further the effects of clozapine on cocaine conditioned place preference. Clozapine (10 mg/kg, s.c.) treatment significantly attenuated the development of cocaine (10mg/kg, i.p.) conditioned place preference. These results, coupled with research that shows clozapine has limited extrapyramidal side effects, suggest that it should be considered as a pharmacotherapy for cocaine abuse. |
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