Cocaine fatalities increased by restraint stress |
| |
| Institution: | 1. Laboratory Medicine, Ospedale San Raffaele, Milan, Italy;2. Biological Variation Working Group, European Federation of Clinical Chemistry and Laboratory Medicine, Belgium;3. Division of Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy;4. Laboratory of Clinical Biochemistry, Haukeland University Hospital, Bergen, Norway;5. Norwegian Quality Improvement of Laboratory Examinations (Noklus), Haraldsplass Deaconess Hospital, Bergen, Norway;6. Acibadem Mehmet Ali Aydinlar University, School of Medicine, Atasehir, Istanbul, Turkey;7. Hospital Universitario La Paz, Quality Analytical Commission of Spanish Society of Clinical Chemistry (SEQC), Madrid, Spain;8. Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway;9. Certe, Wilhelmina Ziekenhuis Assen, Europaweg-Zuid 1, 9401 RK Assen, the Netherlands;10. Central Laboratory, Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico, Milan, Italy |
| |
| Abstract: | Laboratory rats injected daily with a moderate dose of cocaine hydrochloride (30 mg/kg, i.p.) showed increased fatalities when cocaine injections were followed by 30 min of restraint stress. The 5-day mortality rate was 58% for the cocaine-plus-stress group, while 17% of the animals receiving cocaine without restraint stress died. This finding suggests that stress can augment the toxic effect of cocaine and that minimizing stress may be an important consideration in the clinical management of cocaine overdose. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
