Analysis of steroid receptor domains with the aid of antihormones |
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| Institution: | 1. Institute of Postharvest Technology of Agricultural Products, College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, Fujian, 350002, China;2. Key Laboratory of Postharvest Biology of Subtropical Special Agricultural Products (Fujian Agriculture and Forestry University), Fujian Province University, Fuzhou, Fujian, 350002, China;1. Department of Architecture, Catholic University of Daegu, 13-13 Hayang-ro, Hayang-eup, Gyeongsan-si, Gyeongsangbuk-do, Republic of Korea;2. Department of Architecture, Faculty of Engineering, The University of Tokyo, Tokyo, Japan;3. School of Architecture, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, Republic of Korea;1. Departamento de Ciências Naturais, Matemática e Estatística – DCME, Universidade Federal Rural de Semi-Árido – UFERSA, Mossoró, Rio Grande do Norte, Brazil;2. Programa de Pós-Graduação em Sistemas e Computação, Departamento de Informática e Matemática Aplicada – DIMAp, Universidade Federal do Rio Grande do Norte – UFRN, Natal, Rio Grande do Norte, Brazil;3. Departamento de Matemáticas y Física – DMF, Universidad de Magallanes – UMAG, Punta Arenas, Chile;4. Departamento de Estadística, Informática e Matemáticas, Universidad Publica de Navarra, Pamplona, Navarra, 31006, Spain |
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| Abstract: | - 1.1. The receptors for steroid hormones consist of well defined domains with overlapping functions.
- 2.2. Contrary to the classical view, it is now becoming increasingly evident that agonist binding regions of the ligand binding domain are not identical to those that bind steroid antagonists.
- 3.3. The DNA binding domain can be activated equally well in presence of both agonists and antagonists, again contradicting the classical view where only the physiologically active hormone was believed to induce such a change.
- 4.4. In some cases, a synthetic antagonist is a more specific ligand for the receptor than the natural hormone.
- 5.5. Synthetic antagonists are therefore important not only to alleviate disease in the human subject, they have also become an important tool to elucidate the mechanism of transactivation by steroid hormones.
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