Immobilization stress-induced antioxidant defense changes in rat plasma: Effect of treatment with reduced glutathione |
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| Affiliation: | 1. CPQBA, University of Campinas, P.O. Box 6171, 13083-970 Campinas, SP, Brazil;2. GEQOB, ICEx, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil;3. UIC, University of Illinois at Chicago, 3320 MBRB, MC 865 Chicago, IL, USA;4. FCF, University of Campinas, P.O. Box 6029, 13083-859 Campinas, SP, Brazil;1. Division of Anatomy, Department of Biomedical Sciences, Faculty of Allied Health Sciences, Burapha University, 169 Long-Hard Bangsaen Road, SaenSook Sub-district, Mueang District, Chonburi 20131, Thailand;2. Department of Anatomy and Center for Neuroscience, Faculty of Science, Mahidol University, 272 Rama VI Rd., Ratchathewi District, Bangkok 10400, Thailand;1. Medical Affairs Europe and Australia, Grünenthal, Zieglerstrasse 6,52078 Aachen, Germany |
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| Abstract: | - 1.1. We examined immobilization stress-induced antioxidant defense changes in rat plasma and observed the antioxidant effect of reduced glutathione (GSH) administration on these changes.
- 2.2. Immobilization stress induced severe bleeding in the stomach and a significant increase in plasma levels of thiobarbituric acid receives substances (TBARS).
- 3.3. Immobilization stress induced a significant decrease in plasma iron-binding, ironoxidizing protections and radical scavenging activity.
- 4.4. Plasma levels of ascorbic acid, ascorbyl radical and superoxide dismutase activity remained unchanged following immobilization stress.
- 5.5. Treatment with GSH showed a significant protective effect on stomach bleeding, on the increase in plasma TEARS, and on the decrease of iron-binding, iron-oxidizing protection and radical scavenging activity in plasma.
- 6.6. These results suggest that immobilization stress induces generation of reactive oxygen species and decreases the endogenous antioxidant defenses, which can be attenuated by extracellular administration of antioxidant GSH.
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