Involvement of adenosine A1 receptors in antitussive effect in mice |
| |
| Affiliation: | 1. University of Science and Technology of China, Hefei 230026, China;2. High-performance Ceramics Division, Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016, China;1. Department of Pharmacology and Pharemacotherapy, Faculty of Medicine, University of Pécs, Szigeti u. 12, H-7624 Pécs, Hungary;2. MTA-PTE NAP B Pain Research Group & Center for Neuroscience, University of Pécs Medical School, Szigeti u. 12, H-7624 Pécs, Hungary;3. János Szentágothai Research Centre, University of Pécs, Ifjúság u. 34, H-7634 Pécs, Hungary;4. PharmInVivo Ltd., Szondi György u. 10, H-7629 Pécs, Hungary;1. Neuroimmunology of Sepsis Laboratory, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, SP 05508, Brazil;2. Thermoregulation and Systemic Inflammation Laboratory (FeverLab), Trauma Research, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85013, USA |
| |
| Abstract: | The effects of N6-cyclohexyladenosine, a selective adenosine A1 receptor agonist, on the capsaicin-induced cough reflex in mice were examined. I.c.v. administration of N6-cyclohexyladenosine in doses that ranged from 0.03 to 0.3 nmol decreased the number of coughs in a dose-dependent manner. Pretreatment with 8-cyclopentyl-1,3-theophylline, a selective adenosine A1 receptor antagonist, significantly reduced the antitussive effect of N6-cyclohexyladenosine. On the other hand, CGS21680 (0.3 and 1 nmol, i.c.v.), a selective adenosine A2 receptor agonist, had no significant effect on the number of capsaicin-induced coughs. These data suggest that adenosine A1 agonist may have a marked antitussive effect in mice. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
