Antioxidative and antimutagenic effects of theaflavins from black tea |
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| Institution: | 1. Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, People''s Republic of China;2. Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang 110004, People''s Republic of China;1. Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan;2. Bioorganic Research Institute, Suntory Foundation for Life Sciences, 8-1-1, Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan;3. Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Minato-ku, Tokyo 108-8477, Japan;4. Department of Clinical Laboratory Science, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-0942, Japan;5. Department of Biology, College of Liberal Arts and Sciences, Tokyo Medical and Dental University, Ichikawa, Chiba 272-0827, Japan;6. Peptide Institute, Inc., Osaka 567-0085, Japan;7. Organization of Frontier Science and Innovation, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan;8. Department of Anatomy, Showa University School of Medicine, Shinagawa-ku, Tokyo 142-8555, Japan;9. Kambegawa Laboratory, Tokyo 201-0013, Japan;1. Department of Cardiology, China Water Resource and Hyropower, No. 13th, Engineering Bureau Hospital, Dezhou, Shandong 253000, China;2. Department of Respiratory Medicine, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China;3. Department of General Medicine, the Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China |
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| Abstract: | Theaflavins polyphernolic ingredients of black tea, were observed to inhibit in vitro lipid peroxidation in the erythrocyte membrane ghost and microsomal systems. Theaflavins also showed inhibition of DNA single-strand cleavage and mutagenicity, both induced by hydrogen peroxide. These results suggest that theaflavins scavenge radicals to produce antioxidative and antimutagenic effects. It was also found that the gallic acid moiety of theaflavins is essential for their potent antioxidative activities. |
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