Neutrophil proteinases and matrix degradation. The cellbiology of pericellular proteolysis |
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| Institution: | 1. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan;2. Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan;3. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan;4. Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan;5. Research Center for Chinese Herbal Medicine, Research Center for Food and Cosmetic Safety, and Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan;6. Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243, Taiwan;1. Graduate Institute of Biomedical Sciences, Chang Gung University, Kweishan, Taoyuan, Taiwan;2. Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan;3. Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan;4. Division of Engineering in Medicine, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, USA;5. Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, Alexandria, Egypt;6. Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt;7. Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, Saudi Arabia;8. Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan;9. Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan;10. Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan |
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| Abstract: | Neutrophil Proteinases have the capacity to degrade almostevery component of the extracellular matrix. In marked contrast to the wealth of available data about the structure and activity of these proteinases when they are free in solution, there has been relatively little information about the mechanisms by which neutrophils use and control their proteolytic enzymes in an extracellular milieu that is replete with proteinase inhibitors. However, recent data have provided insights into several mechanisms that permit these enzymes to evade inhibition: (1) compartmentalization; (2) localized inactivation of proteinase inhibitors; (3) tight binding of enzymes to substrates; and (4) binding of proteinases to the neutrophil's cell surface. |
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