Precocious cessation of intestinal macromolecular transport and digestive enzymes development by prostaglandin E2 in suckling rats |
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| Affiliation: | 1. Departments of Physiology, Hokkaido University, Sapporo 060, Japan;2. Departments of Anatomy and Biochemistry, Hokkaido University, Sapporo 060, Japan;3. Faculty of Veterinary Medicine, Hokkaido University, Sapporo 060, Japan;1. Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland;2. Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands;3. Department of Food Chemistry and Instrumental Analysis, Poznań University of Life Sciences, Poznań, Poland;4. Department of Food Biotechnology and Microbiology, Poznań University of Life Sciences, Poznań, Poland |
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| Abstract: | The effect of repeated oral administration of prostaglandin analogue (dmPGE2) on intestinal macromolecular transport and digestive enzymes development were investigated in the suckling rats. By the administration of dmPGE2 for 7 days, precocious induction of maltase activity, depression of amylase activity and enhancement of trypsin activity in the pancreas occurred. Absorption of bovine IgG was dose dependently depressed by drnPGE2 treatments. The intestinal cessation was also observed in the adrenalectomized pups, but was not influenced by difluoromethyl ornithine administration. These results suggest that oral administration of PGE2 induces precocious maturation of the small intestine and exocrine pancreas and that the intestinal cessation is not directly related to ornithine decarboxylase activity in the suckling rats. |
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