Characterization of an anion channel in pituitary cells of Gillichthys mirabilis

Patch-clamp studies on pituitary cells from Gillichthys mirabilis show the presence of anion channels with selectivity CI > F = Br = I. These channels are voltage sensitive over the physiological range of membrane potentials and have a unitary conductance of 94 ± 15 pS in symmetrical KCl. Halides other than Cl on the cytoplasmic face of the membrane cause an increase in open probability (P(o)). DPC causes a dose dependent decrease in P(o) without affecting conductance. Sodium on the cytoplasmic face of the membrane causes a decrease in outward current.