Dissociation of temporal and frontal components in the human auditory N1 wave: a scalp current density and dipole model analysis |
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| Institution: | 1. Brain Signals and Processes Laboratory, INSERM-U280, 151 Cours Albert Thomas, 69003 Lyon France;2. MRI Center, Neurological Hospital, 69500 Bron France;1. The Key Laboratory of Biomedical Information of Ministry of Education, Institute of Biomedical Engineering, Xi’an Jiaotong University, Xi’an 710049, China;2. Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, China;3. Department of Neurology, The First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an 710061, China;1. State Key Laboratory of Powder Metallurgy, Central South University, Changsha 410083, China;2. Chongqing University of Arts and Science, Chongqing 402160, China;3. Chengdu Chengliang Tool Group Co., Ltd., Chengdu 610056, China;1. Brain Dynamics Multidisciplinary Research Center, Dokuz Eylül University, Izmir 35340, Turkey;2. Department of Neurosciences, Dokuz Eylül University, Izmir 35340, Turkey;3. Department of Neurology, Dokuz Eylül University Medical School, Balçova, Izmir 35340, Turkey;4. Brain Dynamics, Cognition and Complex Systems Research Center, Istanbul Kultur University, Istanbul 34156, Turkey |
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| Abstract: | This study reports a combined scalp current density (SCD) and dipole model analysis of the N1 wave of the auditory event-related potentials evoked by 1 kHz tone bursts delivered every second. The SCD distributions revealed: (i) a sink and a source of current reversing in polarity at the inferotemporal level of each hemiscalp, compatible with neural generators in and around the supratemporal plane of the auditory cortex, as previously reported; and (ii) bilateral current sinks over frontal areas. Consistently, dynamic dipole model analysis showed that generators in and outside the auditory cortex are necessary to account for the observed current fields between 65 and 140 msec post stimulus. The frontal currents could originate from the motor cortex, the supplementary motor area and/or the cingulate gyrus. The dissociation of an exogenous, obligatory frontal component from the sensory-specific response in the auditory N1 suggests that parallel processes served by distinct neural systems are activated during acoustic stimulation. Implications for recent models of auditory processing are discussed. |
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