Evidence for a dopamine receptor subtype sensitive to combination of D1 with D2 antagonist in measurement of G-protein activity using rat striatal membranes |
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| Affiliation: | 1. University of Oxford, Department of Earth Sciences, Oxford, UK;2. GNS Science, PO Box 30-368, Lower Hutt 5040, New Zealand;3. CIRES & Department of Geological Sciences, University of Colorado, Boulder, CO 80903, USA;4. GEOMAR, Helmholtz Centre for Ocean Research, 24148 Kiel, Germany;5. Imperial College London, Department of Earth Science and Engineering, London SW7 2AZ, UK;6. Petrobras, Rio de Janeiro, Brazil;7. Schlumberger Doll Research, Cambridge, MA, USA;1. LASP, University of Colorado, Boulder, CO, USA;2. Institute of Geological Sciences, Freie Universität Berlin, Germany;3. Space Physics and Astronomy Research Unit, University of Oulu, Finland |
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| Abstract: | In rat striatal membranes, various kinds of dopamine receptor agonists stimulated low-Km GTPase activity in a concentration-dependent manner. This stimulation by bromocriptine, pergolide and apomorphine was partially inhibited by sulpiride (SUL), a D2-selective antagonist, markedly inhibited by combination of SUL with SCH 23390 (SCH), a D1-selective antagonist, and not modified by SCH alone. The stimulation by BAM-1110 was resistant to SUL or SCH alone but abolished by combination of SUL with SCH. These findings suggest the presence of another subtype of a dopamine receptor in a functional in vitro bioassay system in rat striata. |
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