Evaluation of the neurovirulence test for mumps vaccines. |
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| Authors: | M A Afzal S A Marsden R M Hull P A Pipkin M L Bentley P D Minor |
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| Affiliation: | Division of Virology, National Institute for Biological Standards and Control, South Mimms, Potters Bar, Hertfordshire, EN6 3QG, U.K. mafzal@nibsc.ac.uk |
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| Abstract: | Neurovirulence tests in Macaca fascicularis using commercial preparations of different vaccine bulks and a wild-type strain revealed that the test was unable to distinguish mixed from pure populations or a suitable vaccine from a related strain which has been shown to be associated with clinical meningitis. However, the test was able to distinguish a wild-type strain from the vaccine strains successfully. The ability of the test to discriminate between acceptable and unacceptable seeds requires further examination. |
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