Identification of the first human gyrovirus, a virus related to chicken anemia virus |
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Authors: | Sauvage Virginie Cheval Justine Foulongne Vincent Gouilh Meriadeg Ar Pariente Kevin Manuguerra Jean Claude Richardson Jennifer Dereure Olivier Lecuit Marc Burguiere Ana Caro Valérie Eloit Marc |
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Affiliation: | Institut Pasteur, Laboratory for Urgent Responses to Biological Threats, 25 rue du Docteur Roux, F-75015 Paris, France. |
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Abstract: | We have identified in a skin swab sample from a healthy donor a new virus that we have named human gyrovirus (HGyV) because of its similarity to the chicken anemia virus (CAV), the only previously known member of the Gyrovirus genus. In particular, this virus encodes a homolog of the CAV apoptin, a protein that selectively induces apoptosis in cancer cells. By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples. |
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