Insights into cellular factors that regulate HIV-1 replication in human cells |
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Authors: | Lever Andrew M L Jeang Kuan-Teh |
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Affiliation: | Addenbrooke's Hospital, University of Cambridge, Cambridge CB2 0QQ, U.K. |
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Abstract: | Retroviruses integrate into the host cell's chromosome. Accordingly, many aspects of the life cycle of retroviruses like HIV-1 are intimately linked to the functions of cellular proteins and RNAs. In this review, we discuss in brief recent genomewide screens for the identification of cellular proteins that assist HIV-1 replication in human cells. We also review findings for other cellular moieties that help or restrict the viral life cycle. |
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