Interacting genetic factors controlling the antibody response against the H-2.2 specificity |
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Authors: | Martine Decoville R Motta |
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Institution: | (1) Laboratoire d'Immunogénétique, CSEAL-CNRS, Centre Marcel Delépine, 1, rue Haute, 45045 Orléans Cedex, France;(2) Present address: Institut de Cancérologie et d'Immunogénétique, Hôpital Paul Brousse, 94804 Villejuif Cedex, France |
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Abstract: | The antibody response against the H-2.2 specificity has been studied in three H-2
d
strains, B10.D2, DBA/2, and BALB/c, and their hybrids (B10.D2 × DBA/2)F1 and (B10.D2 × BALB/c)F1. The genetic control of the response appears to be complex: The three pure strains are responders, whereas both hybrids when immunized with C3H-HTG are nonresponders. Individual analysis of N3 offspring is compatible with the idea that, in this combination, an Ea-4 incompatibility between donor and immunized strain is necessary for the anti-H-2.2 response to occur. H-2
d
/H-2
k
hybrids (B10.BR × B10.D2)F1 or (B10.BR × DBA/2)F1 are responders when immunized with C57BL/10 (H-2
b
) but not with B10.A(2R) (H-2
h
), indicating that simultaneously recognized H-2 specificities are necessary for the anti-H-2.2 response. |
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Keywords: | |
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