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Effects of different dietary regimes alone or in combination with standardized Aronia melanocarpa extract supplementation on lipid and fatty acids profiles in rats |
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| Authors: | Milic Petar Jeremic Jovana Zivkovic Vladimir Srejovic Ivan Jeremic Nevena Bradic Jovana Nikolic Turnic Tamara Milosavljevic Isidora Bolevich Sergey Bolevich Stefani Labudovic Borovic Milica Arsic Aleksandra Mitrovic Miroslav Jakovljevic Vladimir Vucic Vesna |
| Institution: | 1.High Medical School of Professional Studies in Cuprija, Lole Ribara 1/2, Cuprija, 35 000, Serbia ;2.Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia ;3.Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, Kragujevac, 34 000, Serbia ;4.Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow, Russia, 119991 ;5.Department of Pathophysiology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya street 8, Moscow, Russia, 119991 ;6.Institute of Histology and Embryology “Aleksandar Dj. Kostic”, Faculty of Medicine, University of Belgrade, Dr Subotic 8, Belgrade, 11 000, Serbia ;7.Institute for Medical Research, Centre of Research Excellence in Nutrition and Metabolism, University of Belgrade, Tadeusa Koscuska 1, Belgrade, 11 129, Serbia ;8.Pharmanova, Generala Anrija 6, Belgrade, 11 010, Serbia ; |
| Abstract: | This study investigated different dietary strategies, high-fat (HFd), or standard diet (Sd) alone or in combination with standardized Aronia melanocarpa extract (SAE), as a polyphenol-rich diet, and their effects on lipids and fatty acids (FA) in rats with metabolic syndrome (MetS). Wistar albino rats were randomly divided into two groups: healthy and rats with MetS, and then depending on dietary patterns on six groups: healthy rats fed with Sd, healthy rats fed with Sd and SAE, rats with MetS fed with HFd, rats with MetS fed with HFd and SAE, rats with MetS fed with Sd, and rats with MetS fed with Sd and SAE. 4 weeks later, after an overnight fast (12–14 h), blood for determination of total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), index of lipid peroxidation (measured as TBARS), and FA was collected. Increased FA and lipid concentration found in MetS rats were reduced when changing dietary habits from HFd to Sd with or without SAE consumption. Consumption of SAE slightly affects the FA profiles, mostly palmitoleic acid in healthy rats and PUFA in MetS?+?HFd rats. Nevertheless, in a high-fat diet, SAE supplementation significantly decreases n-6/n-3 ratio, thereby decreasing systemic inflammation. Further researches are warranted to confirm these effects in humans. |
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