|
|||||
|
|
| ALK-mediated Tyr95 phosphorylation of Smad4 impairs its transcription activity and the tumor suppressive activity of TGF-β | |
| 摘 要： | <正>Transforming growth factorβ(TGF-β) regulates various physiological processes such as cell proliferation, differentiation, morphogenesis, andt tissue homeostasis and regeneration. The deregulation of these processes leads to many types of human diseases such as cancer (Massagué,2008). TGF-βsignaling is initiated upon active TGF-βdimer |
| 本文献已被 CNKI SpringerLink 等数据库收录！ | |