Indinavir resistance evolution in one human immunodeficiency virus type 1 infected patient revealed by single-genome amplification

Abstract  

Human Immunodeficiency Virus Type 1 exists in vivo as quasispecies, and one of the genome’s characteristics is its diversity. During the antiretroviral therapy, drug resistance is the main obstacle to effective viral prevention. Understanding the molecular evolution process is fundamental to analyze the mechanism of drug resistance and develop a strategy to minimize resistance.