| 大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响 |
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| 引用本文： | Wang H,Zhu CB,Cao XD,Wu GC. 大鼠中脑导水管周围灰质微量注射孤啡肽对痛和针刺镇痛的影响[J]. 生理学报, 1998, 50(3): 263-267 |
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| 作者姓名： | Wang H Zhu CB Cao XD Wu GC |
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| 作者单位： | 上海医科大学医学神经生物学国家重点实验室,上海,200032 |
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| 基金项目： | 国家自然科学基金,高等学校博士学科点专项科研项目,38870327,32880044,, |
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| 摘 要： | 孤啡肽是新近发现的神经肽,结构与内阿片肽相似,但作用明显不同。本文采用脑核团内微量注射方法,在大鼠电刺激甩尾测痛模型上,观察ＯＦＱ在中脑导水管周围灰质内对痛和针刺镇痛的影响。结果表明：ＰＡＧ内微量注射ＯＦＱ可使大鼠痛阈降低,并明显对抗针刺镇痛;另外还发现,ＯＦＱ在ＰＡＧ内还可以对抗μ受体激动剂羟甲芬太尼加强针刺镇痛的效应。
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| 关 键 词： | 孤啡肽 中脑导水管 周围灰质 针刺镇痛 痛 |
| 修稿时间： | 1997-05-26 |
Effect of orphanin FQ on acupuncture analgesia and noxious stimulation in the periaqueductal gray |
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| Wang H,Zhu C B,Cao X D,Wu G C. Effect of orphanin FQ on acupuncture analgesia and noxious stimulation in the periaqueductal gray[J]. Acta Physiologica Sinica, 1998, 50(3): 263-267 |
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| Authors: | Wang H Zhu C B Cao X D Wu G C |
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| Affiliation: | State Key Laboratory of Neurobiology, Shanghai Medical University, Shanghai 200032. |
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| Abstract: | Orphanin FQ (OFQ) is a newly-discovered neuropeptide which shares great similar sequence with endogenous opioid peptide but with different functions. The present study was to investigate the role of OFQ microinjected in the periaqueductal gray (PAG) on pain threshold and acupuncture analgesia (AA) using tail flick tests. The results show that the hyperalgesia of OFQ and its antagonization on AA in PAG are dose-related. OFQ in PAG decreases the enhancing effect on AA induced by ohmefentanyl, a selective mu-receptor agonist. These observations suggest that OFQ in PAG can increase the rat pain sensitivity and antagonize AA. |
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