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Exploiting dendritic cells for active immunotherapy of cancer and chronic infections |
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| Authors: | David W. O’Neill Nina Bhardwaj |
| Affiliation: | (1) Medicine, Pathology and Dermatology, New York University School of Medicine, Smilow Research Bldg., Room 1301-07, 521 1st Ave., MSB 507, New York, NY 10016, USA;(2) Pathology, New York University School of Medicine, Rusk Research Bldg., Room 718, 400 East 34th Street, NewYork, NY 10016, USA |
| Abstract: | Dendritic cells (DCs) are important antigen-presenting cells (APCs) that can prime naive T cells and control adaptive immune responses with respect to magnitude, memory and self-tolerance. Understanding the biology of these cells is central to the development of new generation immunotherapies for cancer and chronic infections. This review presents a brief overview of DC biology and of the preparation and use of DC-based vaccines. |
| Keywords: | Dendritic Vaccine Antigen presenting Cancer |
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