氧化应激研究进展及其在缺血性心肌病发病中的作用

缺血性心肌病(ischemic cardiomyopathy,ICM)是指由于长期心肌缺血导致心肌局限性或弥漫性纤维化,从而产生心脏收缩和(或)舒张功能受损,引起心脏扩大或僵硬、充血性心力衰竭、心律失常等一系列临床表现的临床综合症。大量研究表明,ICM的发病机制与氧化应激密切相关。研究和开发新的抗氧化药物,将为缺血性心肌病的防治提供新的方向和途径。

Study Progress of Oxidative Stress and Its Effect on Ischemic Cardiomyopathy

Ischemic cardiomyopathy is local or diffuse myocardial fibrosis due to long-term ischemia, resulting in impaired systolic and (or) diastolic function. Patients with this condition may have a series of cllinical menifestations such as enlargement of the heartl, stiff myocardiumt, congestive heart failure and arrhythmia et al. Numerous studies have showed that, ICM is closely related to oxidative stress. Research and development of new antioxidant drug will provide new means for prevention and treatment of ischemic cardiomyopathy.