降钙素基因相关肽与动脉粥样硬化

动脉粥样硬化是心血管疾病中最常见的一种血管病变,影响着血管、免疫、代谢等系统。动脉粥样硬化发生发展是一个复杂的过程,它损伤血管内皮,平滑肌等细胞,涉及到多种细胞因子的相互作用。而CGRP具有抑制血管平滑肌增值作用,对预防血管术后再狭窄有重要意义,CGRP能舒张血管,对防治氧化应激引起的内皮损伤具有保护作用,但其机制还不完全清楚。

Calcitonin Gene Related Peptide and Atherosclerosis

Atherosclerosis is one of the most common angiopathy in cardiovascular disease,it impacts the system of vascular, immune and metabolism. The occurrence and development of atherosclerosis is a complex process,it damages vascular endothelial, smooth muscle and other cells, involves the interaction of multiple cytokines. CGRP can inhibit vascular smooth muscle and play an important role in the prevention of vascular restenosis, CGRP can relax blood vessels,and play a protective role in prevention and treatment of oxidative stress-induced endothelial cell injury, but the mechanism is not fully understood.