蛋白质表面氨基酸特性研究进展

分布在蛋白质分子表面的暴露于溶剂的氨基酸所具有的一些特性对蛋白质的折叠和聚合过程、蛋白质-蛋白质相互作用以及蛋白质的功能具有重要影响。本文分析了蛋白质表面氨基酸在疏水性、保守性、静电势及结构方面的一些特性,阐述了近年来国际上利用这些特性对蛋白质-蛋白质相互作用界面进行预测的方法,最后介绍了几款预测蛋白质表面氨基酸的软件。

Progress in Properties of Amino Acids on Surface of Protein Molecules

The properties of the surface amino acids that exposed to the solvent can influence the fold and polymerizationprocesses, protein-protein interaction and the function of proteins. This paper analyzes the properties of surface amino acids such ashydrophobicity, conservation, electrostatic potential and structural properties. Also, the methods using these properties to predict theinterfaces between two interacting proteins in the international filed were reviewed. Finally we introduced several softwares of predictingsurface amino acids.