The effect on enterotoxicity of protease purified from Vibrio cholerae O1 |
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| Authors: | Yoshio Ichinose Masahiko Ehara Takeshi Honda Toshio Miwatani |
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| Institution: | Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, 1-12-4, Sakamoto, Nagasaki 852, Japan; Department of Bacteriology and Serology, Research Institute for Microbial Diseases, Osaka University, 3-1, Yamadaoka, Suita, Osaka 565, Japan; Faculty of Health and Welfare Science, Okayama Prefectural University, 111, Kuboki, Sohja, Okayama 719-11, Japan |
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| Abstract: | Abstract The effect on enterotoxicity of protease purified from Vibrio cholerae O1 was investigated by the inoculation of live vibrio cells into the protease-treated loops of the ileal loop model. Fluid accumulation ratios in the protease-treated loops were elevated in a dose-dependent manner by challenge with live vibrio cells byt not that with toxin. An enhancement effect of protease on enterotoxicity was observed in both serotypes of V. cholerae O1 and V. cholerae non-O1. It is suggested, therefore, that the enterotoxicity was enhanced by treatment with protease when live vibrio cells were inoculated into the ileal loops of rabbits. |
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| Keywords: | Protease Vibrio cholerae Enterotoxicity |
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