2,3-Bisphosphoglycerate,fructose, 2,6-bisphosphate and glucose 1,6-bisphosphate during maturation of reticulocytes with low 2,3-bisphosphoglycerate content |
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Authors: | Carme Gallego José Carreras |
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Affiliation: | (1) Departament de Ciències Fisiològiques Humanes i de la Nutrició, Unitat de Bioquímica, Facultat de Medicina, Universitat de Barcelona, Zona Universitària de Pedralbes, 08028 Barcelona, Spain |
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Abstract: | In contrast to the species with erythrocytes of high 2,3-bisphosphoglycerate content, in the sheep the concentration of 2,3-bisphosphoglycerate decreases during maturation of reticulocytes. The decrease can be explained by the drop of the phosphofructokinase/pyruvate kinase and 2,3-bisphosphoglycerate synthase/2,3-bisphosphoglycerate phosphatase activity ratios that result from the decline of phosphofructokinase, pyruvate kinase, phosphoglycerate mutase and the bifunctional enzyme 2,3-bisphosphoglycerate synthase/phosphatase. The concentrations of fructose 2,6-bisphosphate and aldohexose 1,6-bisphosphates also decrease during sheep reticulocyte maturation in parallel to the 6-phosphofructo 2-kinase and the glucose 1,6-bisphosphate synthase activities. |
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Keywords: | erythrocyte reticulocyte 2,3-bisphosphoglycerate fructose 2,6-bisphosphate glucose 1,6-bisphosphate 2,3-bisphosphoglycerate synthase/phosphatase |
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