Cellular aspects of tolerance. VII. Inheritance of the resistance to tolerance induction |
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Authors: | M Fujiwara B Cinader |
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Affiliation: | Institute of Immunology, Departments of Medical Genetics, Medical Biophysics, and Clinical Biochemistry, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada M5S 1A8 |
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Abstract: | The half-lives of elimination () of 131I-RGG from the body of normal A or Balb/c animals was much longer than the of SJL mice. At all ages, the of normal hybrids (A × SJL, SJL × A, Balb/c × SJL) was similar to or longer than that of the A or Balb/c parents. Thus, in terms of the of normal animals, the SJL responsiveness to 131I-RGG appeared to be a recessive trait. Tolerance could be induced in newborn animals and, in terms of , the degree of unresponsiveness at the age of 6 weeks, was the same in A, Balb/c, A × SJL, and Balb/c × SJL animals but was much shorter in SJL mice. Thus, in neonatally induced tolerance, the duration of tolerance was recessive for the SJL type. The average after tolerance induction in 3-week-old hybrids (A × SJL, SJL × A, Balb/c × SJL) was similar to that of the A or Balb/c parent, but by the 8th and 12th week it approached the average of the SJL parent. Comparing 8-week-old hybrids, the average was longest in A × SJL hybrids and identical in SJL × A and Balb/c × SJL mice. An examination of distribution in various 8- and 12-week-old crosses and backcrosses revealed a fairly large proportion of individuals with a which was intermediate between SJL and the other parent. There was a tendency for this number to decrease in 12 weeks as compared to 8-week-old mice. In 8-week-old mice, the number of animals with intermediate was smallest when SJL was the maternal animal [(SJL × A); SJL × (A × SJL); SJL × (SJL × A)]. There was no link between of tolerant animals and either the immunoglobulin allotype (MuAl/MuA2) or the C5 eniotype (MuB1 positive/MuB1 negative). |
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Keywords: | IFA Incomplete Freund's adjuvant PBS Phosphate-buffered saline RGG Rabbit γ-globulin Half-life of antigen elimination |
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