The 3-D structure of HIV-1 proteinase and the design of antiviral agents for the treatment of AIDS |
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| Authors: | T L Blundell R Lapatto A F Wilderspin A M Hemmings P M Hobart D E Danley P J Whittle |
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| Affiliation: | Department of Crystallography, Birkbeck College, London, UK. |
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| Abstract: | A proteinase is essential for replication of HIV. Cloning and chemical synthesis have provided a sufficient supply of HIV-1 proteinase for the determination of its three-dimensional structure. Analogies between the structures of HIV-1 proteinase and the mammalian enzyme renin, which is involved in the control of blood pressure, have given important clues concerning the design of specific inhibitors that have antiviral activity. |
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