Genomic organization, proposed alternative splicing mechanisms, and RNA editing structure of GRIK1 |
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| Authors: | Barbon A Barlati S |
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| Affiliation: | Division of Biology and Genetics, Department of Biomedical Sciences and Biotechnologies, Brescia University Medical School, Italy. |
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| Abstract: | In the present study, we report the genomic reconstruction of the glutamate receptor GluR5 gene (GRIK1, alias GLUR5; 402 kb) by the use of the data available in public databases. This analysis allowed characterization of the exon-intron boundaries, identification of the gene promoter region, presentation of the putative complete sequences of two GluR5 mRNA isoforms, and definition of the structure of GluR5 pre-mRNA surrounding the Q/R editing site. |
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