The HP0256 gene product is involved in motility and cell envelope architecture of <Emphasis Type="Italic">Helicobacter pylori</Emphasis> |
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| Authors: | François P Douillard Kieran A Ryan Michael C Lane Delphine L Caly Stanley A Moore Charles W Penn Jason Hinds Paul W O'Toole |
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| Institution: | (1) Department of Microbiology & Alimentary Pharmabiotic Centre, University College Cork, Cork, Ireland;(2) Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada;(3) School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK;(4) Bacterial Microarray Group, Division of Cellular and Molecular Medicine, St George's University of London, Cranmer Terrace, London, UK |
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| Abstract: | Background
Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella
that are essential for colonisation and persistence in the gastric mucosa. The biochemistry and genetics of flagellar biogenesis
in H. pylori has not been fully elucidated. Bioinformatics analysis suggested that the gene HP0256, annotated as hypothetical, was a FliJ
homologue. In Salmonella, FliJ is a chaperone escort protein for FlgN and FliT, two proteins that themselves display chaperone activity for components
of the hook, the rod and the filament. |
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