Identification of intestinal M cells in isolated lymphoid follicles and Peyer’s patches of the Angora rabbit |
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Authors: | Feyzullah Beyaz Emel Ergün Alev G Bayraktaroğlu Levent Ergün |
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Institution: | 1. Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Erciyes, Bar?? Man?o cad. No:1, 38090, Kayseri, Turkey 2. Department of Histology and Embryology, Faculty of Veterinary Medicine, University of K?r?kkale, K?r?kkale, Turkey 3. Department of Histology and Embryology, Faculty of Veterinary Medicine, University of Ankara, D??kap? Campus, Ankara, Turkey
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Abstract: | The presence, distribution, and localization of M cells in isolated lymphoid follicles (ILF) and in follicle-associated epithelia
(FAE) covering Peyer’s patches (PP) in Angora rabbits were investigated by immunohistochemistry and electron microscopy. Although
PP could macroscopically be identified along the length of the mucosal and serosal surfaces of jejunum and ileum, the presence
of ILF could only be located microscopically. Typical M cells in FAE were detected within the periphery of the dome regions
of the PP, and immature columnar M cells in the FAE resided in the vicinity of the crypts. M cells in the FAE of both ILF
and PP showed vimentin-positive reaction. M cells in the FAE of ILF were morphologically similar to the immature M cells found
in the FAE of PP. Typical mature M cells were also observed in the FAE of a few ILF. In contrast to FAE of PP, numerous goblet
cells were observed in the FAE of many ILF. Moreover, among intestinal villi, we noticed villi-like solitary lymphoid structures
that showed abundant lymphocytes in their lamina propria and that were surrounded with vimentin-positive cells and goblet
cells. Thus, the occurrence of copious immature M cells and goblet cells, in addition to the detection of villi-like solitary
lymphoid structures full of lymphocytes in the FAE of many ILF, indicate that ILF do not complete their immunological maturation
in contrast to PP. Various antigenic stimulations conceivably induce the formation and maturation of ILF along the length
of the small intestine. The morphological resemblance between ILF M cells and PP M cells suggests that these two types of
cells perform similar or the same immunological functions. |
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