Asc1p,a ribosomal protein,plays a pivotal role in cellular adhesion and virulence in <Emphasis Type="Italic">Candida albicans</Emphasis> |
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Authors: | Se Woong Kim Yoo Jin Joo Joon Kim |
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Institution: | (1) Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, 202002, India;(2) Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA;(3) Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, 202002, India;(4) Department of Microbiology, JN Medical College, Aligarh Muslim University, Aligarh, 202002, India;(5) DNA Research Chair, Department of Zoology, King Saud University, Riyadh, Saudi Arabia |
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Abstract: | Candida albicans, the common human fungal pathogen, can switch morphology from yeast to pseudohyphal or hyphal form upon various environmental
cues. It is well-known that the ability of morphological conversion and adhesive growth renders C. albicans virulent. It is noteworthy that every factor involved in the morphogenesis is known to be important for the virulence of
this pathogen. To examine a functional relevance of Asc1p, a ribosomal protein, in morphogenesis and virulence, an asc1 homozygous null mutant was generated. Although a normal morphological transition of the asc1 deletion strain in liquid media was found, it did not change its morphology on solid media. Moreover, the adhesion activity
and hyphal-specific gene expression were defective due to ASC1 deletion. Finally, it was found that the asc1 null mutant was avirulent in a mouse model. These results strongly suggested that Asc1p a component of the 40S ribosomal
subunit and a signal transducer, plays a pivotal role in cellular adhesion and virulence through regulation of specific gene
expression in C. albicans. |
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