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The binding of folyl polyglutamates by hemoglobin |
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| Authors: | Reinhold Benesch Samuel Waxman Ruth Benesch Charles Baugh |
| Affiliation: | 1. Department of Biochemistry, College of Physicians and Surgeons Columbia University, New York, New York, USA;2. Cancer Chemotherapy Foundation Laboratory, Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA;3. Department of Biochemistry, School of Medicine, University of South Alabama, Mobile, Alabama, USA |
| Abstract: | Pteroyl polyglutamates bind to hemoglobin with an affinity which leaves only a minor fraction of red cell folate in the free state. This could serve as a regulating mechanism for protein synthesis in the differentiating erythroblast. |
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