Compactin inhibits insect HMG-CoA reductase and juvenile hormone biosynthesis |
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Authors: | Daniel J. Monger Wendell A. Lim Ferenc J. Kézdy John H. Law |
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Affiliation: | Department of Biochemistry, The University of Chicago, Chicago, IL 60637 USA |
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Abstract: | The activity of 3-hydroxy-3-methylglutaryl CoA reductase in homogenates of the corpora allata of the tobacco hornworm, , was competitively inhibited by compactin. The KI for the sodium salt form of compactin was 0.9 nM for the reductase from both male and female corpora allata. In intact female corpora allata juvenile hormone biosynthesis was also inhibited by approximately 50 percent at 10 nM compactin. Following injection with compactin, darkening of the cuticle, an indication of juvenile hormone deficiency, was observed in larvae after ecdysis from third to fourth instar. Hence, compactin shows potential as an inhibitor of insect growth and development. |
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Keywords: | Present address: Department of Biochemistry University of Arizona Tucson AZ Address correspondence to this author. |
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