Inhibition of respiration by a phorbol ester tumor promoter in murine cultured cells |
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Authors: | Joseph M. Backer Michael R. Boersig I.Bernard Weinstein |
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Affiliation: | 1. Division of Environmental Sciences Columbia University New York, New York 10032 USA;2. Cancer Center/Institute of Cancer Research Columbia University New York, New York 10032 USA |
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Abstract: | The tumor promoter 12-O-tetradecanoyl phorbol-13-acetate is a potent inhibitor of mitochondrial respiration in both normal and methylcholanthrene-transformed C3H mouse fibroblasts. This inhibition is seen at concentrations of tumor promoter in the range of 10?8M, occurs within a few minutes after exposure of the intact cells, and is not seen with a biologically inactive analog. The effect appears to be exerted through inhibition of the function of an oligomycin-sensitive ATPase. It is possible, therefore, that alterations in mitochondrial function are associated with the process of tumor promotion. |
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Keywords: | TPA 12-O-tetradecanoyl-phorbol-13-acetate DMSO dimethylsulfoxide FCCP cyanide p-trifluoromethoxy-phenyl hydrazone |
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