Reciprocal changes in fructose-6-phosphate,2-kinase and fructose-2,6-bisphosphatase activity in response to glucagon and epinephrine |
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Authors: | Carolyn Sue Richards Motoko Yokoyama Eisuke Furuya Kosaku Uyeda |
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Affiliation: | 1. Veterans Administration Medical Center, Dallas, Texas 75216 USA;2. the University of Texas Health Science Center, Department of Biochemistry, Dallas, Texas 75235 USA |
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Abstract: | The effect of hormones on the enzymes responsible for the synthesis (fructose-6-P,2-kinase) and degradation (fructose-2,6-Pase) of fructose-2,6-P2 was examined in isolated rat hepatocytes. Glucagon (10?11 M), epinephrine (10?5 M), or calcium (2.4 mM) and A23187 (10?5 M) administration to hepatocytes produced simultaneous activation of fructose-2,6-Pase and inactivation of fructose-6-P,2-kinase within 2 minutes. The effect of epinephrine on these two enzymes was dependent on the presence of Ca++. These results suggest that the level of fructose-2,6-P2 is controlled by recriprocal changes in fructose-2,6-Pase and fructose-6-P,2-kinase activities. |
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