Effect of cysteamine on amino acid pools of cultured fibroblasts and the uptake of L-proline |
| |
| Authors: | Beatrice States Stanton Segal |
| |
| Affiliation: | 1. Division of Biochemical Development and Molecular Diseases, The Children''s Hospital of Philadelphia, Philadelphia, PA 19104 USA;2. Department of Medicine, University of Pennsylvania School of Medicine Philadelphia, PA 19104 USA;3. Department of Pediatrics, University of Pennsylvania School of Medicine Philadelphia, PA 19104 USA |
| |
| Abstract: | Cysteamine when incubated with human normal and cystinotic fibroblasts produces significant alterations in cellular amino acid pools with a decrease in proline, glycine, histidine, and methionine as well as branch chain and dibasic amino acids. Serine content was increased while aspartate, glutamate and glutamine were unchanged. The uptake of L-proline by cysteamine treated cells was impaired suggesting that altered uptake of amino acids may be a factor in the cysteamine effect. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
