Iron enhances the bactericidal action of streptonigrin |
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Authors: | James R. White Heather N. Yeowell |
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Affiliation: | Department of Biochemistry and Nutrition University of North Carolina at Chapel Hill Chapel Hill, NC 27514 USA |
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Abstract: | The lethal action of streptonigrin on strains of is greatly enhanced by citrate (10?2 M). Desferrioxamine (2×10?4 M), when added with streptonigrin and citrate, eliminates the citrate enhancement. These observations point to a role for iron in the bactericidal mechanism of streptonigrin. Extracellular citrate is known to promote the acquisition of iron by by delivering it as a ferric citrate complex to a specific transport apparatus on the cell envelope. Therefore, it may promote action of streptonigrin by increasing the intracellular concentration of available iron. Desferrioxamine, which forms a much stronger complex with ferric ion than does citrate, would be expected to suppress the ferric citrate effect, and this was observed. |
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