Kinetic constanis of asialoorosomucoid endocytosis comparison between hepatocytes from normal and streptozotocin-diabetic rats |
| |
Authors: | Michèle Dodeur Jean-Pierre Dumont Dominique Durand Geneviève Durand Jean Agneray Jeanne Feger |
| |
Institution: | 1. Laboratoire de Neuro-Endocrinologie, U 159, I.N.S.E.R.M., 2 ter rue d''Alesia 75014 Paris - France. |
| |
Abstract: | The initial velocity of asialoorosomucoid internalization is determined for normal and diabetic rat hepatocytes. The analysis of results according to Woolf-Hofstee's method, showed no modification of the endocytosis constant. In contrast, the maximum velocity of asialoorosomucoid internalization is decreased by threefold in diabetic rat hepatocytes as compared to normal rat hepatocytes. No modification of internalization constant is observed between the two groups of rats. This suggests that the decrease of asialoorosomucoid total uptake, previously reported for diabetic rat hepatocytes is directly related to a decrease of total surface receptor number. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |