Inhibition of β-adrenergic stimulation of lymphocyte adenylate cyclase by phorbol myristate acetate is mediated by activated macrophages |
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| Authors: | Abraham Novogrodsky Miriam Patya Albert L Rubin Kurt H Stenzel |
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| Institution: | 1. The Rogoff-Wellcome Medical Research Institute, Beilinson Medical Center, Petah-Tikva, Israel;2. Tel-Aviv University Sackler Medical School, Israel;3. the Rogosin Kidney Center, Department of Biochemistry, Cornell University Medical College, New York, New York 10021 USA.;4. Department of Medicine, Cornell University Medical College, New York, New York 10021 USA. |
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| Abstract: | Phorbol myristate acetate, a tumor promoter and lymphocyte mitogen, inhibits isoproterenol-stimulated adenylate cyclase in human peripheral blood mononuclear cells. Catalase and superoxide dismutase and depletion of macrophages from the cell preparations reversed this inhibitory effect. Phorbol myristate acetate did not inhibit isoproterenol-stimulated adenylate cyclase in purified T-cells or in membrane preparation from turkey erythrocytes. Thus, inhibition of adenylate cyclase activity by phorbol myristate acetate in human peripheral blood mononuclear cells is an indirect effect resulting from production of oxy radicals by activated macrophages. |
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