Estradiol receptors in articular chondrocytes |
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| Authors: | Itzhak A Rosner Andrea Manni Charles J Malemud Beata Boja Roland W Moskowitz |
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| Institution: | 1. Cartilage Research Laboratory Department of Medicine Case Western Reserve University School of Medicine Cleveland, Ohio 44106 USA;2. Division of Endocrinology Department of Medicine Case Western Reserve University School of Medicine Cleveland, Ohio 44106 USA |
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| Abstract: | Recent experimental studies suggest a role for estrogens in chondrocyte metabolism and the development and treatment of osteoarthritis. Type I cytoplasmic estradiol receptors were found in articular chondrocytes. The presence of these receptors supports a possible mechanism for previous observations on estrogen suppressive effects on cartilage proteoglycan synthesis and offers a basis for further study on the role of estrogens in the physiology of cartilage and in the pathogenesis and treatment of osteoarthritis. |
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