首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Sex Bias in Susceptibility to MCMV Infection: Implication of TLR9
Authors:Stephanie Traub  Olivier Demaria  Lionel Chasson  Fabienne Serra  Benoit Desnues  Lena Alexopoulou
Institution:1. Centre d''Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université UM 2, Marseille, France.; 2. Institut National de la Santé et de la Recherche Médicale (INSERM) UMR 1104, Marseille, France.; 3. Centre National de la Recherche Scientifique (CNRS), UMR 7280, Marseille, France.; National Institute of Allergy and Infectious Diseases - Rocky Mountain Laboratories, United States of America,
Abstract:Toll-like receptor (TLR)-dependent pathways control the activation of various immune cells and the production of cytokines and chemokines that are important in innate immune control of viruses, including mouse cytomegalovirus (MCMV). Here we report that upon MCMV infection wild-type and TLR7−/− male mice were more resistant than their female counterparts, while TLR9−/− male and female mice showed similar susceptibility. Interestingly, 36 h upon MCMV infection TLR9 mRNA expression was higher in male than in female mouse spleens. MCMV infection led to stronger reduction of marginal zone (MZ) B cells, and higher infiltration of plasmacytoid dendritic cells and neutrophils in wild-type male than female mice, while no such sex differences were observed in TLR9−/− mice. In accordance, the serum levels of KC and MIP-2, major neutrophil chemoattractants, were higher in wild-type, but not in TLR9−/−, male versus female mice. Wild-type MCMV-infected female mice showed more severe liver inflammation, necrosis and steatosis compared to infected male mice. Our data demonstrate sex differences in susceptibility to MCMV infection, accompanied by a lower activation of the innate immune system in female mice, and can be attributed, at least in a certain degree, to the lower expression of TLR9 in female than male mice.
Keywords:
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号