| Abstract: | Differences in the composition of the gut microbial community have been associated withdiseases such as obesity, Crohn''s disease, ulcerative colitis and colorectal cancer(CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA geneto characterize adherent bacterial communities in mucosal biopsy samples from 33 subjectswith adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjectswith adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa weremore abundant in control samples. The magnitude of the differences in the distal gutmicrobiota between patients with adenomas and controls was more pronounced than that ofany other clinical parameters including obesity, diet or family history of CRC. Thissuggests that sequence analysis of the microbiota could be used to identify patients atrisk for developing adenomas. |
